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ribophorin-2; dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2; dolichyl-diphosphooligosaccharide-protein glycosyltransferase 63 kD subunit; RIBIIR; RPN-II (RPN2)
Function:
- essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to Asn within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains
- component of the oligosaccharyltransferase (OST) complex
Structure: belongs to the SWP1 family
Compartment:
- endoplasmic reticulum membrane
- multi-pass membrane protein (putative)
Alternative splicing: named isoforms=2
Expression: expressed in all tissues tested
General
glycoprotein
phosphoprotein
ribophorin (Sec61p)
transmembrane 3 protein
Properties
SIZE: entity length = 631 aa
MW = 69 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: exoplasmic domain {1-540}
MOTIF: signal sequence {1-22}
N-glycosylation site {N106}
Thr phosphorylation site {T282}
transmembrane domain {541-561}
cytoplasmic loop {562-571}
transmembrane domain {572-592}
exoplasmic loop {593-596}
transmembrane domain {597-617}
cytoplasmic domain {618-631}
SUBUNITS: ribophorin-alpha
MOTIF: membrane region
ribophorin-beta
MOTIF: membrane region {C-TERMINAL}
ribophorin-gamma
MOTIF: membrane region {C-TERMINAL}
Database Correlations
OMIM 180490
UniProt P04844
Pfam PF05817
Entrez Gene 6185
Kegg hsa:6185
ENZYME 2.4.1.119
References
UniProt :accession P04844
Component-of
N-oligosaccharyl transferase (OST)
Components
ribophorin-alpha; sec61p-alpha
ribophorin-beta; sec61p-beta
ribophorin-gamma; sec61p-gamma