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ribonuclease P (RNase P, RNase MRP)
Function:
1) endonuclease that generates mature tRNA molecules by cleaving their 5'-ends
2) endonucleolytic cleavage of RNA, removing extra 5'-nucleotides from tRNA precursor
Structure:
- RNase P consists of a RNA moiety & at least 9 protein subunits, POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38, RPP40
Compartment: nucleus, nucleolus
General
molecular complex
ribonuclease (RNase)
Properties
MOTIF: active site
SUBUNITS: ribonuclease P protein subunit p14
ribonuclease P protein subunit p20
ribonuclease P protein subunit p25
ribonuclease P protein subunit p29
MOTIF: Ser phosphorylation site {S10}
lysine-rich region {65-74}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S145}
Tyr phosphorylation site {Y150}
Thr phosphorylation site {T161}
ribonuclease P protein subunit p30
MOTIF: Ser phosphorylation site {S251}
ribonuclease P protein subunit p38
MOTIF: lysine-rich region {63-68}
MOTIF: lysine residue (SEVERAL)
ribonuclease P protein subunit p40
ribonucleases P/MRP protein subunit POP1
MOTIF: Thr phosphorylation site {T365}
Ser phosphorylation site {S367}
Ser phosphorylation site {S371}
Thr phosphorylation site {T404}
Ser phosphorylation site {S584}
Ser phosphorylation site {S730}
ribonucleases P/MRP protein subunit POP5
MOTIF: Ser phosphorylation site {S154}
References
UniProt :accession O75792
Components
ribonuclease P protein subunit p14 (RNaseP protein p14, RPP14)
ribonuclease P protein subunit p20 (RNaseP protein p20, hPOP7, POP7, RPP20)
ribonuclease P protein subunit p25 (RNaseP protein p25, RPP25)
ribonuclease P protein subunit p29 (hPOP4, RNaseP protein p29, RPP29)
ribonuclease P protein subunit p30 (RNaseP protein p30, RNase P subunit 2, RPP30, RNASEP2)
ribonuclease P protein subunit p38 (RNaseP protein p38, RPP38)
ribonuclease P protein subunit p40 (RNaseP protein p40, rRNase P subunit 1, RPP40, RNASEP1)
ribonucleases P/MRP protein subunit POP1 (hPOP1, POP1, KIAA0061)
ribonucleases P/MRP protein subunit POP5 (hPOP5, POP5)