ribonuclease H2 (RNase H2)

Function: 1) endonuclease that specifically degrades the RNA of RNA:DNA hybrids 2) DNA replication 3) mediates the removal of lagging-strand Okazaki fragment RNA primers during DNA replication (putative) 4) mediates the excision of single ribonucleotides from DNA:RNA duplexes. 5) endonucleolytic cleavage to 5'-phosphomonoester 6) heterotrimer composed of the a) RNASEH2A (catalytic) b) RNASEH2B, RNASEH2C (regulatory) Compartment: nucleus

General

molecular complex ribonuclease (RNase)

Properties

MOTIF: active site SUBUNITS: ribonuclease H2 subunit A ribonuclease H2 subunit B ribonuclease H2 subunit C

References

UniProt :accession O75792

Components

ribonuclease H2 subunit A (RNase H2 subunit A, ribonuclease HI subunit A, ribonuclease HI large subunit, RNase HI large subunit, RNase H35, Aicardi-Goutieres syndrome 4 protein, AGS4, RNASEH2A, RNASEHI, RNHIA) ribonuclease H2 subunit B (RNase H2 subunit B, ribonuclease HI subunit B, Aicardi-Goutieres syndrome 2 protein, AGS2, RNASEH2B, DLEU8) ribonuclease H2 subunit C (RNase H2 subunit C, ribonuclease HI subunit C, Aicardi-Goutieres syndrome 3 protein, AGS3, RNase H1 small subunit, RNASEH2C, AYP1)