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ribonuclease 1 (RNase 1, ribonuclease-A, RNase-A, RNase UPI-1, pancreatic ribonuclease)
Function:
- endonuclease catalyzes cleavage of RNA on 3' side of pyrimidine nucleotides
- acts on single stranded RNA & double stranded RNA
- endonucleolytic cleavage to nucleoside 3'-phosphates & 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates
Structure:
- monomer
- belongs to the pancreatic ribonuclease family
- glycoprotein, N-linked glycans are of complex type
Compartment: secreted
Expression:
- pancreas & other tissues & body fluids (suggesting it may have other physiological functions besides its role in digestion)
General
endoribonuclease
glycoprotein
pancreatic ribonuclease family
secreted protein
Properties
SIZE: entity length = 156 aa
MW = 18 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-28}
binding site
SITE: 35-35
FOR-BINDING-OF: Substrate
binding site
SITE: 38-38
FOR-BINDING-OF: Substrate
histidine residue {H40}
cysteine residue {C54}
MODIFICATION: cysteine residue {C112}
N-glycosylation site {N62}
cysteine residue {C68}
MODIFICATION: cysteine residue {C123}
Substrate binding {69-73}
cysteine residue {C86}
MODIFICATION: cysteine residue {C138}
cysteine residue {C93}
MODIFICATION: cysteine residue {C100}
binding site
SITE: 94-94
FOR-BINDING-OF: Substrate
cysteine residue {C100}
MODIFICATION: cysteine residue {C93}
N-glycosylation site {N104}
cysteine residue {C112}
MODIFICATION: cysteine residue {C54}
binding site
SITE: 113-113
FOR-BINDING-OF: Substrate
N-glycosylation site {N116}
cysteine residue {C123}
MODIFICATION: cysteine residue {C68}
cysteine residue {C138}
MODIFICATION: cysteine residue {C86}
histidine residue {H147}
Database Correlations
OMIM correlations
UniProt P07998
Pfam PF00074
ENZYME 3.1.27.5
References
UniProt :accession P07998