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ribonuclease 7; Rnase 7; skin-derived antimicrobial protein 2; SAP-2 (RNASE7)
Function:
- potent Rnase activity
- broad-spectrum antimicrobial activity against many pathogenic microorganisms, including:
- vancomycin-resistant Enterococcus faecium (VRE) (lethal dose of 90% < 30 nM)
Structure: belongs to the pancreatic ribonuclease family
Compartment: secreted
Expression:
- expressed in various epithelial tissues including: skin, respiratory tract, genito-urinary tract > GI tract
- expressed in liver, kidney, skeletal muscle & heart
General
endoribonuclease
glycoprotein
Properties
SIZE: entity length = 156 aa
MW = 17 kD
MOTIF: signal sequence {1-28}
histidine residue {H43}
cysteine residue {C51}
MODIFICATION: cysteine residue {C109}
cysteine residue {C65}
MODIFICATION: cysteine residue {C119}
Substrate binding {66-70}
cysteine residue {C83}
MODIFICATION: cysteine residue {C134}
cysteine residue {C90}
MODIFICATION: cysteine residue {C97}
binding site
SITE: 91-91
FOR-BINDING-OF: Substrate
cysteine residue {C97}
MODIFICATION: cysteine residue {C90}
cysteine residue {C109}
MODIFICATION: cysteine residue {C51}
cysteine residue {C119}
MODIFICATION: cysteine residue {C65}
N-glycosylation site {N127}
cysteine residue {C134}
MODIFICATION: cysteine residue {C83}
histidine residue {H151}
Database Correlations
UniProt Q9H1E1
Pfam PF00074
Entrez Gene 84659
Kegg hsa:8465
References
UniProt :accession Q9H1E1