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Rho-guanine nucleotide exchange factor p190; p190RhoGEF (RGNEF, ARHGEF28, KIAA1998)
Function:
- RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins & growth factor receptors
- functions in axonal branching, synapse formation & dendritic morphogenesis
- functions also in focal adhesion formation, cell motility & B-lymphocytes activation
- may regulate NEFL expression & aggregation & play a role in apoptosis (putative)
- phosphorylated on Tyr upon stimulation of cells by laminin (putative)
- forms a complex with MAPK8 & MAPK8IP1
- interacts with RHOA
- interacts with microtubules
- interacts with YWHAE & YWHAH
- interacts with PTK2
- interacts with NEFL (putative)
- interacts with CTNND2
- prevents interaction with RHOA
Structure:
- homooligomer, forms cytoplasmic aggregates
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
- contains 1 phorbol-ester/DAG-type Zn+2 finger
Compartment:
- cytoplasm (putative), cell membrane
- colocalizes with the microtubule radial & cortical systems (putative)
Alternative splicing: named isoforms=4
General
rho guanine nucleotide exchange factor
zinc finger protein
Properties
SIZE: entity length = 1705 aa
MW = 192 kD
COMPARTMENT: cytoplasm
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 652-699
EFFECTOR-BOUND: Zn+2
Dbl homology domain {849-1044}
PH domain {1086-1188}
PTK2 interaction {1295-1304}
YWHAH interaction {1372-1383}
microtubule interaction {1425-1705}
MOTIF: coiled coil {1488-1525}
binding site
SITE: 1496-1527
FOR-BINDING-OF: ribonucleic acid
MAPK8IP1 interaction {1566-1579}
Database Correlations
UniProt Q8N1W1
PFAM correlations
References
UniProt :accession Q8N1W1