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Rho guanine nucleotide exchange factor 5; ephexin-3; guanine nucleotide regulatory protein TIM; oncogene TIM; transforming immortalized mammary oncoprotein; p60 TIM (ARHGEF5, TIM)
Structure:
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
- contains 1 SH3 domain
Alternative splicing: named isoforms=2
Expression:
- mainly expressed in kidney, liver, pancreas, lung & placenta
Genetics:
- a segmental duplication of chromosome 7 involving ARHGEF5 is one of the few features distinguishing the human genome from the chimpanzee genome [2]
Related
ARHGEF5 (rho guanine nucleotide exchange factor 5) gene (transforming immortalized mammary oncogene, TIM)
General
evolutionary divergent human protein
phosphoprotein
rho guanine nucleotide exchange factor
Properties
SIZE: entity length = 1597 aa
MW = 177 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S184}
Ser phosphorylation site {S445}
Ser phosphorylation site {S450}
Ser phosphorylation site {S1126}
Dbl homology domain {1174-1358}
PH domain {1390-1502}
src homology 3 [SH3] domain
SITE: 1513-1569
Database Correlations
OMIM 600888
UniProt Q12774
PFAM correlations
Entrez Gene 7984
Kegg hsa:7984
References
- UniProt :accession Q12774
- Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L,
Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-
Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM.
Lineage-specific gene duplication and loss in human and great
ape evolution.
PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13.
PMID: 15252450