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Rho guanine nucleotide exchange factor 3; exchange factor found in platelets & leukemic & neuronal tissues (XPLN, ARHGEF3)
Function:
- acts as guanine nucleotide exchange factor (GEF) for RhoA & RhoB GTPases
- interacts with RHOA & RHOB
Structure:
- contains 1 DH domain (DBL-homology domain) contains 1 PH domain
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- expressed in adult brain & skeletal muscle > heart & kidney
General
rho guanine nucleotide exchange factor
Properties
SIZE: MW = 60 kD
entity length = 526 aa
COMPARTMENT: cytoplasm
MOTIF: Dbl homology domain {122-304}
PH domain {291-449}
Database Correlations
UniProt Q9NR81
PFAM correlations
Entrez Gene 50650
References
UniProt :accession Q9NR81