Rho guanine nucleotide exchange factor 17; 164 kD Rho-specific guanine-nucleotide exchange factor; p164-RhoGEF; p164RhoGEF; tumor endothelial marker 4 (ARHGEF17, KIAA0337, TEM4)

Function: - guanine nucleotide exchange factor (GEF) for RhoA GTPases Structure: contains 1 DH (DBL-homology) domain Expression: highly expressed in the heart

General

phosphoprotein rho guanine nucleotide exchange factor

Properties

SIZE: entity length = 2063 aa MW = 222 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S138} Ser phosphorylation site {S142} glutamine-rich region {201-204} MOTIF: glutamine residue (SEVERAL) serine-rich region {230-235} MOTIF: serine residue (SEVERAL) glutamate-rich region {252-256} MOTIF: glutamate residue (SEVERAL) serine-rich region {566-569} MOTIF: serine residue (SEVERAL) serine-rich region {672-675} MOTIF: serine residue (SEVERAL) arginine-rich region {707-710} MOTIF: arginine residue (SEVERAL) proline-rich region SITE: 963-1054 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1002} Dbl homology domain {1066-1254} proline-rich region SITE: 1990-1996 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt Q96PE2 Pfam PF00621 Entrez Gene 9828 Kegg hsa:9828

References

UniProt :accession Q96PE2