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Rho guanine nucleotide exchange factor 15; ephexin-5; E5; Vsm-RhoGEF (ARHGEF15, KIAA0915)
Function:
- specific GEF for RhoA activation
- does not activate RAC1 or CDC42
- regulates vascular smooth muscle contractility
- negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2
- phosphorylated on Tyr upon EFNA1 stimulation EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination (putative)
- ubiquitinated; UBE3A-mediated ubiquitination & degradation by the proteasome promotes EFNB1-dependent synapse formation
- interacts with EPHB2 (putative)
- interacts with EPHA4
Structure: contains 1 DH (DBL-homology) domain
Compartment:
- cell projection, dendrite (putative)
Expression:
- dendrites of the developing hippocampus (putative)
- expressed in the vascular smooth muscle of coronary artery
- seems to be some confusion here (see UniProt [1])
General
phosphoprotein
rho guanine nucleotide exchange factor
Properties
SIZE: entity length = 841 aa
MW = 92 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 7-133
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S84}
Tyr phosphorylation site {Y353}
Dbl homology domain {417-601}
Database Correlations
OMIM 608504
UniProt O94989
Pfam PF00621
Entrez Gene 22899
Kegg hsa:22899
References
- UniProt :accession O94989