Rho guanine nucleotide exchange factor 11; PDZ-RhoGEF (ARHGEF11, KIAA0380)

Function: - may play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) & guanine nucleotide-binding alpha-13 (GNA13) - acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase & may act as GTPase-activating protein (GAP) for GNA12 & GNA13 - interacts with GNA12 & GNA13 through the RGS domain - interacts with RHOA, PLXNB1 & PLXNB2 - interacts with SLC1A6 Structure: - the poly-Pro region is essential for plasma membrane localization upon stimulation - contains 1 DH (DBL-homology) domain - contains 1 PDZ domain (DHR domain) - contains 1 PH domain - contains 1 RGSL (RGS-like) domain Compartment: - cytoplasm, membrane - translocated to the membrane upon stimulation Expression: ubiquitously expressed

General

phosphoprotein rho guanine nucleotide exchange factor

Properties

SIZE: entity length = 1522 aa MW = 168 kD COMPARTMENT: cytoplasm MOTIF: PDZ domain NAME: PDZ domain SITE: 47-126 Ser phosphorylation site {S245} Ser phosphorylation site {S251} Thr phosphorylation site {T254} Ser phosphorylation site {S255} RGSL {306-486} MOTIF: coiled coil {444-470} Ser phosphorylation site {S663} Thr phosphorylation site {T668} Thr phosphorylation site {T672} Dbl homology domain {734-923} PH domain {965-1079} proline-rich region SITE: 1094-1099 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1155} Ser phosphorylation site {S1295} Ser phosphorylation site {S1300} Ser phosphorylation site {S1457} Ser phosphorylation site {S1458} Thr phosphorylation site {T1462} Thr phosphorylation site {T1475} Ser phosphorylation site {S1480} Ser phosphorylation site {S1489} Ser phosphorylation site {S1491}

Database Correlations

OMIM 605708 UniProt O15085 PFAM correlations Entrez Gene 9826 Kegg hsa:9826

References

UniProt :accession O15085