Rho guanine nucleotide exchange factor 10-like protein (grinchGEF, ARHGEF10L, GRINCHGEF, KIAA1626)

Function: - acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB & RHOC - interacts with RHOA, RHOB & RHOC Structure: contains 1 DH (DBL-homology) domain Compartment: cytoplasm Alternative splicing: named isoforms=5 Expression: - detected in heart, liver, skeletal muscle, kidney & pancreas

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: entity length = 1279 aa MW = 140 kD COMPARTMENT: cytoplasm MOTIF: Tyr phosphorylation site {Y131} Tyr phosphorylation site {Y152} Dbl homology domain {316-503}

Database Correlations

UniProt Q9HCE6 Pfam PF00621

References

UniProt :accession Q9HCE6