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Rho guanine nucleotide exchange factor 10 (ARHGEF10, KIAA0294)
Function:
- may play a role in developmental myelination of peripheral nerves
Structure: contains 1 DH (DBL-homology) domain
Alternative splicing: named isoforms=5
Pathology:
- defects in ARHGEF10 are the cause of slowed nerve conduction velocity
General
phosphoprotein
rho guanine nucleotide exchange factor
Properties
SIZE: entity length = 1369 aa
MW = 152 kD
COMPARTMENT: cell nucleus
MOTIF: coiled coil {304-355}
Ser phosphorylation site {S379}
Dbl homology domain {421-608}
serine-rich region {1271-1304}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S1284}
Ser phosphorylation site {S1287}
Database Correlations
OMIM correlations
MORBIDMAP 608136
UniProt O15013
Pfam PF00621
Entrez Gene 9639
Kegg hsa:9639
References
UniProt :accession O15013