Rho guanine nucleotide exchange factor 1; 115 kD guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; sub1.5 (ARHGEF1)

Function: - seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) & guanine nucleotide-binding alpha-13 (GNA13) subunits - acts as GTPase-activating protein (GAP) for GNA12 & GNA13, & as guanine nucleotide exchange factor (GEF) for RhoA GTPase - activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain - RhoGEF activity is inhibited by binding to activated GNA12 - mediates angiotensin-2-induced RhoA activation - phosphorylated by PKCA - angiotensin-2 induced Tyr-738 - phosphorylation is mediated by JAK2 - interacts with RHOA, GNA12 & GNA13 - homooligomerizes through the coiled coil region - may interact with CCPG1 - interacts with CTNNAL1 Structure: - the RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity - the DH domain is involved in interaction with CCPG1 - contains 1 DH (DBL-homology) domain - contains 1 PH domain - contains 1 RGSL (RGS-like) domain Compartment: - cytoplasm, membrane - translocated to the membrane by activated GNA13 or LPA stimulation Alternative splicing: named isoforms=3 Expression: ubiquitously expressed

General

phosphoprotein rho guanine nucleotide exchange factor

Properties

SIZE: entity length = 912 aa MW = 102 kD COMPARTMENT: cytoplasm MOTIF: RGSL {41-232} Dbl homology domain {416-605} PH domain {647-760} MOTIF: Tyr phosphorylation site {Y738} Ser phosphorylation site {S863} coiled coil {865-896}

Database Correlations

OMIM 601855 UniProt Q92888 PFAM correlations Entrez Gene 9138 Kegg hsa:9138

References

UniProt :accession Q92888