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Rho-GTPase-activating protein 5 (p190-B, ARHGAP5, RHOGAP5)
Function:
- GTPase-activating protein for all rho subfamily proteins
- formation of a complex between ras-GAP & ARHGAP5 in growth-stimulated cells may allow coupling of signalling pathways that involve ras & rho GTPases
- may play a role in the reduction of the p21ras GTPase-activating potential of p120GAP
Structure:
- contains 4 FF domains
- contains 1 Rho-GAP domain
Compartment:
- cytoplasm, peripheral membrane
- membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin
Expression: expressed in kidney, brain, liver & lung
Interactions
molecular events
General
rho GTPase-activating protein (rho-GAP)
Properties
SIZE: MW = 172 kD
entity length = 1499 aa
COMPARTMENT: cytoplasm
MOTIF: FF domain {269-325}
FF domain {365-420}
FF domain {427-482}
FF domain {483-537}
lysine-rich region {1224-1242}
MOTIF: lysine residue (SEVERAL)
rho-GAP domain
NAME: rho-GAP domain
SITE: 1259-1446
Database Correlations
OMIM 602680
UniProt Q13017
PFAM correlations
Entrez Gene 394
References
- Hunter T.
Cooperation between oncogenes.
Cell. 1991 Jan 25;64(2):249-70. Review.
PMID: 1988147
- Settleman J, Albright CF, Foster LC, Weinberg RA.
Association between GTPase activators for Rho and Ras families.
Nature. 1992 Sep 10;359(6391):153-4.
PMID: 1522900
- UniProt :accession Q13017
Component-of
molecular complex