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rho/rac GDP dissociation inhibitor

Inhibits dissociation of GDP from rac & rho-G. Removes rho proteins from cellular membranes in cell-free systems.

Interactions

molecular events

Specific

Rho GDP-dissociation inhibitor 1; Rho GDI 1; Rho-GDI alpha (ARHGDIA GDIA1) Rho GDP-dissociation inhibitor 2; Rho GDI 2; Rho-GDI beta; Ly-GDI (ARHGDIB, GDIA2, GDID4, RAP1GN1) Rho GDP-dissociation inhibitor 3 (Rho GDI 3, Rho-GDI gamma)

General

GDP dissociation inhibitor (GDI)

Properties

COMPARTMENT: cytoplasm SIZE: MW = 26-28 kD entity length = 294 aa MOTIF: binding site FOR-BINDING-OF: rho subfamily protein

References

  1. Segal AW, Abo A. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci. 1993 Feb;18(2):43-7. Review. PMID: 8488557
  2. Hart MJ, Maru Y, Leonard D, Witte ON, Evans T, Cerione RA. A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs. Science. 1992 Oct 30;258(5083):812-5. PMID: 1439791
  3. Fukumoto Y, Kaibuchi K, Hori Y, Fujioka H, Araki S, Ueda T, Kikuchi A, Takai Y. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene. 1990 Sep;5(9):1321-8. PMID: 2120668
  4. Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: 8259209

Component-of

molecular complex