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rho GTPase-activating protein (rho-GAP)
Specific
250 kD substrate of Akt (RALGAPA2, AS250, C20orf74, KIAA1272)
beta-chimaerin (CHN2, rho GTPase-activating protein 3, rhoGAP3, arhGAP3, chimaerin-2)
breakpoint cluster region protein P160 (p160BCR)
Cdc42 GTPase-activating protein (CDGAP, ARHGAP31, KIAA1204)
DEP domain-containing protein 1A (DEPDC1A, DEPDC1)
DEP domain-containing protein 1B; HBxAg-transactivated protein 8 (DEPDC1B, XTP8)
drosophila rotund protein
GEM-interacting protein (GMIP)
glucocorticoid receptor DNA-binding factor 1; glucocorticoid receptor repression factor 1; GRF-1; Rho GAP p190A; p190-A (GRLF1, GRF1, ARHGAP35, KIAA1722)
minor histocompatibility protein HA-1 ([contains: minor histocompatibility antigen HA-1 (mHag HA-1)], HMHA1 KIAA0223)
n-chimaerin (neuronal chimaerin, alpha-chimerin, A-chimaerin, Rho GTPase-activating protein 2, CHN1, ARHGAP2, CHN)
oligophrenin-1 (OPHN1)
protein C5orf5; GAP-like protein N61 (FAM13B)
Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2, Graf-related protein 2, ARHGAP10, GRAF2)
Rho GTPase-activating protein 10-like (ARHGAP10L, ARHGAP42)
Rho GTPase-activating protein 11A (ARHGAP11A, KIAA0013)
Rho GTPase-activating protein 11B (Rho-type GTPase-activating protein 11B, ARHGAP11B)
Rho GTPase-activating protein 12; Rho-type GTPase-activating protein 12 (ARHGAP12)
Rho GTPase-activating protein 15 (Rho-type GTPase-activating protein 15, ArhGAP15, ARHGAP15)
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH-1, ARHGAP17, RICH1, MSTP066, MSTP110)
Rho GTPase-activating protein 18 (MacGAP, ARHGAP18)
Rho GTPase-activating protein 18-like (ARHGAP40)
Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19, ARHGAP19)
Rho GTPase-activating protein 20 (ARHGAP20, KIAA1391)
Rho GTPase-activating protein 21 (Rho-type GTPase-activating protein 21, Rho GTPase-activating protein 10, ARHGAP21, ARHGAP10, KIAA1424)
Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22, ARHGAP22, RHOGAP2)
Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23, ARHGAP23, KIAA1501)
Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24, filamin-A-associated RhoGAP, FilGAP, p73RhoGAP, RhoGAP of 73 kD, RAC1 & CDC42-specific GTPase-activating protein of 72 kD, RC-GAP72, sarcoma antigen NY-SAR-88, ARHGAP24, FILGAP)
Rho GTPase-activating protein 25; Rho-type GTPase-activating protein 25 (ARHGAP25, KIAA0053)
Rho GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase; oligophrenin-1-like protein; Rho-type GTPase-activating protein 26 (ARHGAP26, GRAF, KIAA0621, OPHN1L)
Rho GTPase-activating protein 27 (Rho-type GTPase-activating protein 27, CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, ARHGAP27, CAMGAP1, PP905)
Rho GTPase-activating protein 28 (ARHGAP28, KIAA1314)
Rho GTPase-activating protein 29 (Rho-type GTPase-activating protein 29, PTPL1-associated RhoGAP protein 1, ARHGAP29, PARG1)
Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30, ARHGAP30)
Rho GTPase-activating protein 33; Rho-type GTPase-activating protein 33; Tc10/CDC42 GTPase-activating protein; sorting nexin-26 (ARHGAP33, SNX26, TCGAP)
Rho GTPase-activating protein 7; deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12 (DLC1, ARHGAP7, KIAA1723, STARD12)
Rho GTPase-activating protein 8 (ARHGAP8)
Rho GTPase-activating protein 9; Rho-type GTPase-activating protein 9 (ARHGAP9)
Rho GTPase-activating protein FLJ46335 (ARHGAP36)
Rho GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; RICH-2; NPC-A-10 (RICH2, ARHGAP44, KIAA0672)
Rho GTPase-activating protein SYDE1 (protein syd-1 homolog 1, synapse defective protein 1 homolog 1, SYDE1)
Rho GTPase-activating protein SYDE2 (protein syd-1 homolog 2, synapse defective protein 1 homolog 2, SYDE2)
Rho-GTPase-activating protein 1 (Rho-related small GTPase protein activator, CDC42 GTPase-activating protein, P50-rhoGAP, ARHGAP1)
Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1, ARHGAP4, P115)
Rho-GTPase-activating protein 5 (p190-B, ARHGAP5, RHOGAP5)
Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein 6, RhoGAPX-1)
Rho/Cdc42/Rac GTPase-activating protein RICS; p200RhoGAP; p250GAP; RhoGAP involved in the beta-catenin-N-cadherin & NMDA receptor signaling; brain-specific Rho GTPase-activating protein; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAP; GTPase regulator interacting with TrkA (RICS, GRIT, KIAA0712, ARHGAP32)
SH3 domain-binding protein 1; 3BP-1 (SH3BP1)
SLIT-ROBO Rho GTPase-activating protein 1; srGAP1; Rho GTPase-activating protein 13 (SRGAP1, ARHGAP13, KIAA1304)
SLIT-ROBO Rho GTPase-activating protein 2; srGAP2; formin-binding protein 2; Rho GTPase-activating protein 34 (SRGAP2, ARHGAP34, FNBP2, KIAA0456, SRGAP2A)
SLIT-ROBO Rho GTPase-activating protein 2B; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2 (SRGAP2B, SRGAP2P2)
SLIT-ROBO Rho GTPase-activating protein 2C; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1 (SRGAP2C, SRGAP2P1)
SLIT-ROBO Rho GTPase-activating protein 3; srGAP3; mental disorder-associated GAP; Rho GTPase-activating protein 14; WAVE-associated Rac GTPase-activating protein; WRP; srGAP2 (SRGAP3, ARHGAP14, KIAA0411, KIAA1156, MEGAP, SRGAP2)
StAR-related lipid transfer protein 13; 46H23.2; deleted in liver cancer 2 protein; DLC-2; START domain-containing protein 13; StARD13 (STARD13, DLC2, GT650)
T-cell activation Rho GTPase-activating protein; T-cell activation GTPase-activating protein (TAGAP, TAGAP1, FKSG15)
General
GTPase-activating protein (GAP)
Properties
SIZE: MW = 27.5 kD
MOTIF: phosphorylation site
domain {C-TERMINAL}
MOTIF: active site
binding site
FOR-BINDING-OF: rho subfamily protein
HOMOLOGY: p160BCR
beta-chimaerin
n-chimaerin
Rho-GTPase-activating protein 5
rho-GAP
SH3 domain-binding protein 1
PI-3-kinase p85
drosophila rotund protein
Database Correlations
OMIM 300023
References
- Garrett MD, Major GN, Totty N, Hall A.
Purification and N-terminal sequence of the p21rho GTPase-
activating protein, rho GAP.
Biochem J. 1991 Jun 15;276 ( Pt 3):833-6.
PMID: 1905930
- Boguski MS & McCormick F
Proteins regulating Ras and its relative.
Nature 366:643 1993
PMID: 8259209