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rho6 protein (Rho-related GTP-binding protein Rho6, Rnd1)
Function:
- binds plexin B1, grb7
- lacks intrinsic GTPase activity
- has a low affinity for GDP, & constitutively binds GTP
- controls rearrangements of the actin cytoskeleton
- induces the Rac-dependent neuritic process formation, in part by disruption of the cortical actin filaments
- causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments
- binds GRB7 & PLXNB1
- interacts with UBXD5
Structure: belongs to the small GTPase superfamily, Rho family
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side.
- cytoplasm
- cytoskeleton
Expression: mostly expressed in brain & liver
Interactions
molecular events
General
rho subfamily protein
Properties
SIZE: entity length = 232 aa
MW = 26 kD
COMPARTMENT: cytoplasm
MOTIF: GTP-binding site
SITE: 20-27
Effector region {42-50}
GTP-binding site
SITE: 67-71
GTP-binding site
SITE: 125-128
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 609038
UniProt Q92730
Pfam PF00071
Entrez Gene 27289
Kegg hsa:27289
References
Uniprot :accession Q92730
Component-of
molecular complex