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rhombotin-2; LIM domain only protein 2; cysteine-rich protein TTG-2; T-cell translocation protein 2 (LMO2, RBTN2, RBTNL1, RHOM2, TTG2)
Function:
- acts with TAL1/SCL to regulate red blood cell development
- also acts with LDB1 to maintain erythroid precursors in an immature state
- interacts via its LIM domains with ELF2 & LBD1
- also interacts with basic helix-loop-helix protein TAL1/SCL & can assemble in a complex with LMO2 & TAL1/SCL (putative)
- interacts with BEX2 & KDM5A
Structure:
- the second LIM Zn+2-binding domain interacts with KDM5A
- contains 2 LIM Zn+2-binding domains
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Pathology:
- chromosomal translocation t(11;14)(p13;q11) involving LMO2 with TCRD may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL)
Related
LMO2 gene
General
LIM domain protein
nuclear protein
Properties
SIZE: entity length = 158 aa
MW = 18 kD
COMPARTMENT: cell nucleus
MOTIF: LIM domain {30-89}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {94-153}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Database Correlations
OMIM 180385
UniProt P25791
Pfam PF00412
Entrez Gene 4005
Kegg hsa:4005
References
- UniProt :accession P25791
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/RBTN2ID34.html