rhombotin-1; LIM domain only protein 1; cysteine-rich protein TTG-1; T-cell translocation protein 1 (LMO1, RBTN1, RHOM1, TTG1)

Function: - may be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors Structure: contains 2 LIM Zn⁺²-binding domains Compartment: nucleus (putative) Expression: - expressed mainly in the central nervous system - low level of expression in other tissues including thymus Pathology: - chromosomal translocation t(11;14)(p15;q11) involving LMO1 with TCRD may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL)

General

LIM domain protein nuclear protein

Properties

SIZE: entity length = 156 aa MW = 18 kD COMPARTMENT: cell nucleus MOTIF: LIM domain {24-83} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {88-147} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site

Database Correlations

OMIM 186921 UniProt P25800 Pfam PF00412 Entrez Gene 4004 Kegg hsa:4004

References

UniProt :accession P25800