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Rhomboid family member 1 (p100hRho, Rhomboid 5 homolog 1, RHBDF1, C16orf8)
Function:
- not expected to have protease activity
- N-glycosylated
Structure:
- homodimer, or homooligomer
- interacts with TGFA & HBEGF
- belongs to the peptidase S54 family
- lacks the conserved Ser in position 720 essential for serine protease activity; enzyme activity is thus unlikely
Compartment:
- endoplasmic reticulum membrane
- Golgi apparatus membrane
- predominantly localized in the endoplasmic reticulum membrane
Expression:
- highly expressed in heart, skeletal muscle, placenta & pancreatic islet
- detected at lower levels in colon, kidney, small intestine & lung
General
glycoprotein
transmembrane 7c protein
Properties
SIZE: entity length = 855 aa
MW = 97 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: cytoplasmic domain {1-411}
transmembrane domain {412-432}
exoplasmic loop {433-655}
MOTIF: N-glycosylation site {N583}
transmembrane domain {656-676}
cytoplasmic loop {677-691}
transmembrane domain {692-712}
exoplasmic loop {713-714}
transmembrane domain {715-735}
cytoplasmic loop {736-746}
transmembrane domain {747-767}
exoplasmic loop {768-772}
transmembrane domain {773-793}
cytoplasmic loop {794-803}
transmembrane domain {804-824}
exoplasmic domain {825-855}
Database Correlations
UniProt Q96CC6
Pfam PF01694
Kegg hsa:6428
References
UniProt :accession Q96CC6