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zinc finger protein RFP; Ret finger protein; tripartite motif-containing protein 27; RING finger protein 76 (TRIM27, RFP, RNF76)
Function:
- has transcriptional repressor activity by cooperating with EPC1
- induces apoptosis by activating Jun N-terminal kinase & p38 kinase & also increases caspase-3-like activity independently of mitochondrial events
- may function in male germ cell development
- has DNA-binding activity & preferentially binds double-stranded DNA (putative)
- homomultimerizes
- interacts with PML, EIF3S6, EPC1, CHD4 & EID1
Structure:
- the coiled-coil region mediates interaction with EPC1 & CHD4
- the B box & coiled-coil domains mediate interaction with PML
- the B box & the distal coiled-coil domains mediate homomultimerisation
- the B30.2 domain mediates interaction with EIF3S6
- belongs to the TRIM/RBCC family
- contains 1 B box-type Zn+2 finger
- contains 1 B30.2/SPRY domain
- contains 1 RING-type Zn+2 finger
Compartment:
- nucleus (putative). cytoplasm
- nuclear or cytoplasmic depending on the cell type (putative)
- colocalized with PML & EIF3S6 in nuclear bodies
Alternative splicing: named isoforms=2; alpha, beta
Expression:
- expressed in testis namely within the seminiferous tubules
Pathology:
- chromosomal translocation t(6;10)(p21.3;q11.2) involving TRIM27 with RET is a cause of thyroid papillary carcinoma; the translocation generates RFP/RET & delta RFP/RET oncogenes
Related
Ret finger protein-like 1; RING finger protein 78 (RFPL1, RFPL1L, RNF78)
Ret finger protein-like 2; RING finger protein 79 (RFPL2, RNF79)
Ret finger protein-like 3 (RFPL3)
General
DNA-binding protein
proto oncogene protein
ring finger protein
Properties
SIZE: entity length = 513 aa
MW = 58 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RING-finger {16-57}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 96-127
EFFECTOR-BOUND: Zn+2
coiled coil {132-172}
coiled coil {282-311}
B30.2/SPRY {298-492}
MOTIF: breakpoint {315-316}
Database Correlations
OMIM correlations
UniProt P14373
PFAM correlations
Entrez Gene 5987
Kegg hsa:5987
References
UniProt :accession P14373