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retroviral-like aspartic protease 1 (skin-specific retroviral-like aspartic protease, skin aspartic protease, SASPase, TPA-inducible aspartic proteinase-like protein, TAPS, ASPRV1, SASP)
Function:
- undergoes autocleavage, necessary for activation
Structure:
- homodimer
- contains 1 peptidase A2 domain
Compartment:
- membrane
Expression:
- expressed primarily in the granular layer of epidermis & inner root sheath of hair follicles
Pathology:
- in psoriatic skin, expressed throughout the stratum corneum
- in ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent from ulcerated regions
- expressed in differentiated areas of squamous cell carcinomas but not in undifferentiated tumors
General
aspartic proteinase; carboxyl acid protease
glycoprotein
membrane protein
Properties
SIZE: MW = 37 kD
entity length = 343 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {56-76}
Peptidase A2 {207-288}
MOTIF: aspartate residue {D212}
N-glycosylation site {N276}
Database Correlations
UniProt Q53RT3
References
UniProt :accession Q53RT3