retrotransposon-derived protein PEG10 (paternally expressed gene 10 protein, retrotransposon-derived gag-like polyprotein, embryonal carcinoma differentiation-regulated protein, mammalian retrotransposon-derived protein 2, myelin expression factor 3-like protein 1, MEF3-like protein 1, retrotransposon gag domain-containing protein 3, Ty3/Gypsy-like protein, PEG10, EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG3)

Function: - inhibits apoptosis through interaction with SIAH1, a mediator of apoptosis - may also have a role in cell growth promotion - inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1 - when overexpressed, induces formation of cellular extension, such as filipodia in association with ALK1 - involved at the immediate early stage of adipocyte differentiation (putative) - may bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter - interacts with ALK1, SIAH1 & SIAH2 - isoform RF1/RF2 undergoes proteolytic cleavage Structure: contains 1 CCHC-type Zn⁺² finger Compartment: - nucleus, cytoplasm - detected predominantly in the cytoplasm of carcinomas - colocalized with ALK1 ribosomal frameshifting; Named isoforms=2 Expression: - expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta - expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue & placenta - expressed in placenta during the first trimester of gestation (at protein level) - in placenta, down- regulated at early hypoxic phase, & highly activated at 11-12 week of gestation - up-regulated by MYC & dihydrotestosterone (DHT) Pathology: - expressed in pancreatic cancer & hepatocellular carcinoma - may have a role in hepatoma formation - prevents apoptosis in hepatocellular carcinoma cells through interaction with SIAH1 - expressed in prostate cancers & breast carcinomas but not in normal breast & prostate epithelial cells Genetics: - the PEG10 locus is imprinted, giving rise to paternally expressed proteins

General

nuclear protein zinc finger protein

Properties

SIZE: entity length = 708 aa MW = 80 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {1-50} Necessary for interaction with ALK1 {76-275} Zn finger C2HC-type SITE: 293-310 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 682-703 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt Q86TG7 PFAM correlations Kegg hsa:2308

References

UniProt :accession Q86TG7