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retinoid X receptor (RXR)
Function:
- binds to DNA as heterodimer with retinoic acid receptor, vitamin D3 receptor, thyroid hormone receptor & LX nuclear receptor
- cytoplasmic anchoring associated with hsp90
- ligands include 9-cis-retinoic acid & docosahexaenoic acid
Interactions
molecular events
Related
heat shock protein [hsp]-90
LX nuclear receptor (LXR, oxysterol receptor)
retinoic acid receptor (RAR)
triiodothyronine [T3] receptor or erbA proto-oncogene protein
vitamin D3 receptor; VDR; 1,25-dihydroxyvitamin D3 receptor; nuclear receptor subfamily 1 group I member 1 (VDR, NR1I1)
Specific
retinoic acid receptor RXR-alpha; retinoid X receptor alpha; nuclear receptor subfamily 2 group B member 1 (RXRA, NR2B1)
retinoic acid receptor RXR-beta; retinoid X receptor beta; nuclear receptor subfamily 2 group B member 2 (RXRB, NR2B2)
retinoic acid receptor RXR-gamma; retinoid X receptor gamma; nuclear receptor subfamily 2 group B member 3 (RXRG, NR2B3)
General
nuclear hormone receptor NR2 subfamily
Properties
COMPARTMENT: cytoplasm
MOTIF: allosteric site
DNA-binding motif
MOTIF: kxffkr
NAME: kxffkr
FOR-BINDING-OF: calreticulin
FORM: kxffkr
Zinc finger
NAME: Zinc finger (2)
EFFECTOR-BOUND: Zn+2
ligand-binding site
FOR-BINDING-OF: 9-cis retinoic acid
References
- Alberts et al Molecular Biology of the Cell,
2nd ed. 1989, pg 704
- Green S.
Nuclear hormone receptors. Promiscuous liaisons.
Nature. 1993 Feb 18;361(6413):590-1.
PMID: 8382343
- de Urquiza AM et al
Docosahexaenoic acid, a ligand for the retinoid X receptor
in mouse brain.
Science. 2000 Dec 15;290(5499):2140-4.
PMID: 11118147
Component-of
molecular complex