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retinoic acid receptor responder protein 2 (tazarotene-induced gene 2 protein, RAR-responsive protein TIG2, RARRES2,TIG2)
Compartment: secreted
Expression:
- highly expressed in skin (basal & suprabasal layers of epidermis, hair follicles, endothelial cells)
- also found in pancreas, liver, spleen, prostate, ovary, small intestine, colon
Pathology:
- inhibited in psoriatic lesions
- activated by tazarotene in epidermis of psoriatic lesions
General
secreted protein
Properties
SIZE: MW = 19 kD
entity length = 163 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-16}
Database Correlations
OMIM 601973
UniProt Q99969
References
UniProt :accession Q99969