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retinoic acid early transcript 1G protein (RAET1G)
Function:
- ligand for the NKG2D receptor
- mediates NK cell cytotoxicity
- binds to KLRK1/NKG2D & CMV glycoprotein UL16
Structure: belongs to the MHC class 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression: highly expressed in colon
Pathology:
- high expressed in a number of tumor cell lines
General
cell surface receptor
Properties
SIZE: MW = 37 kD
entity length = 334 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-25}
MHC class I alpha-1 like {29-117}
MOTIF: cysteine residue {C50}
MODIFICATION: cysteine residue {C66}
cysteine residue {C66}
MODIFICATION: cysteine residue {C50}
N-glycosylation site {N82}
MHC class I alpha-2 like {118-210}
MOTIF: cysteine residue {C127}
MODIFICATION: cysteine residue {C190}
cysteine residue {C190}
MODIFICATION: cysteine residue {C127}
transmembrane domain {224-243}
Database Correlations
UniProt Q6H3X3
Pfam PF00129
References
UniProt :accession Q6H3X3