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retinoblastoma-associated protein-like p107 homolog; retinoblastoma-like protein 1; PRB1; 107 kD retinoblastoma-associated protein; p107 (RBL1)
Function:
- key regulator of entry into cell division
- directly involved in heterochromatin formation by maintaining overall chromatin structure &, in particular, that of constitutive heterochromatin by stabilizing histone methylation
- recruits & targets histone methyltransferases SUV420H1 & SUV420H2, leading to epigenetic transcriptional repression
- controls histone H4 Lys-20 trimethylation
- probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters
- potent inhibitor of E2F-mediated trans-activation
- forms a complex with adenovirus E1A & with SV40 large T antigen
- may bind & modulate functionally certain cellular proteins with which T & E1A compete for pocket binding
- may act as a tumor suppressor
- interacts with SUV420H1 & SUV420H2 (putative)
- component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 & TFDP2
- the complex exists in quiescent cells where it represses cell cycle-dependent genes
- dissociates in S phase when LIN9, LIN37, LIN52 & LIN54 form a subcomplex that binds to MYBL2
- interacts with AATF
- interacts with JARID1A
- exists in both phosphorylated & unphosphorylated forms
- SV40 large T antigen, but not E1A, binds only to the unphosphorylated form
- cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 & Ser-975 by CDK4
Structure: belongs to the retinoblastoma protein (RB) family
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Related
Rb-related protein p130; retinoblastoma-like protein 2; RBR-2; PRB2; 130 kD retinoblastoma-associated protein; p130 (RBL2 RB2)
retinoblastoma-associated protein (pRb, Rb, pp110, p105-Rb, p110Rb, RB1)
General
phosphoprotein
transcription factor (TF)
Properties
SIZE: MW = 121 kD
entity length = 1068 aa
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T332}
Thr phosphorylation site {T369}
Pocket
NAME: Pocket
SITE: 385-949
FOR-BINDING-OF: nucleolar transcription factor 1
SV40 T antigen
adenovirus E1a
E2F
MOTIF: Domain A {385-584}
Thr phosphorylation site {T385}
Spacer {585-780}
Ser phosphorylation site {S640}
Ser phosphorylation site {S650}
Ser phosphorylation site {S762}
Domain B {781-949}
Ser phosphorylation site {S964}
Ser phosphorylation site {S975}
Ser phosphorylation site {S988}
Thr phosphorylation site {T997}
Ser phosphorylation site {S1009}
Database Correlations
OMIM 116957
UniProt P28749
PFAM correlations
Entrez Gene 5933
Kegg hsa:5933
References
- UniProt :accession P28749
- Entrez Gene :accession 5933
Component-of
corepressor complex