retinitis pigmentosa 9 protein (pim-1-associated protein, PAP-1, RP9)

Function: 1) target protein for the PIM1 kinase (putative) 2) role in B-cell proliferation in association with PIM1 3) binds to PIM1, ZNHIT4 Compartment: nucleus Expression: - expressed in a wide range of tissues Pathology: - defects in RP9 are the cause of retinitis pigmentosa 9

General

C2H2 type zinc finger protein nuclear protein phosphoprotein

Properties

SIZE: MW = 26 kD entity length = 221 aa COMPARTMENT: cell nucleus MOTIF: binding site SITE: 1-155 FOR-BINDING-OF: pim-1 proto-oncogene MOTIF: Zn finger C2HC-type SITE: 104-122 EFFECTOR-BOUND: Zn+2 serine-rich region {174-179} MOTIF: serine residue (SEVERAL) lysine-rich region {182-213} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S212} Ser phosphorylation site {S214}

Database Correlations

OMIM correlations MORBIDMAP 607331 UniProt Q8TA86

References

UniProt :accession Q8TA86