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reticulocyte count

Reference interval: - 0.5-1.5% - 25,000-75,000/uL, 23-90,000/uL [1] Clinical significance: - reticulocyte count is an indication of the erythropoietic response to anemia - it is useful for classifying anemia as hypoplastic vs blood loss or hemolysis - corrected measures are often applied based upon an expected increase in reticulocyte production in response to anemia - 1st correction = reticulocyte index - (Hgb patient/Hgb control) x reticulocyte count Increases: - increased levels > 100,000/uL a) hemolytic anemia b) hemorrhage (3-4 days later) c) replacement of hematic factor - iron, folate, vitamin B12 d) sickle cell anemia e) post splenectomy f) pregnancy g) polycythemia Decreases: - hypoplastic anemia a) inflammation with low erythropoietin (most common) b) nutritional deficiencies - vitamin B12 deficiency, pernicious anemia - folic acid deficiency - iron deficiency [1] c) endocrine disorders - adrenocortical hypofunction - hypothyroidism - testosterone deficiency - anterior pituitary hypofunction d) aplastic anemia, pure red cell aplasia e) radiation therapy g) chronic infection h) cirrhosis i) malignancy, myelodysplasia

Related

reticulocyte

Specific

reticulocytes immature in blood reticulocytes in blood from fetus

General

clinical hematology test

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, 17 American College of Physicians, Philadelphia 1998, 2015 - Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  2. Mosby's Diagnostic and Laboratory Test Reference, 9th edition, Pagana DS and Pagana TJ editors, Mosby, Elsevier, St. Louis, 2009
  3. Reticulocytes Percent Laboratory Test Directory ARUP: 40022
  4. Mini Panel of 2 tests: Cellular Hemoglobin, Retic . Reticulocytes Percent Laboratory Test Directory ARUP: 40263

Component-of

anemia panel deprecated CBC with reticulocyte count hemolysis panel