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reticulocalbin-1 (RCN1, RCN)
Function:
- may regulate Ca+2-dependent activities in the endoplasmic reticulum lumen or post-ER compartment
Structure:
- belongs to the CREC family
- contains 6 EF-hand domains
a) four functional Ca+2-binding sites
b) potential sites 2 & 6 have lost affinity for Ca+2
Compartment:
- endoplasmic reticulum lumen
General
glycoprotein
reticulocalbin
Properties
SIZE: entity length = 331 aa
MW = 39 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-29}
N-glycosylation site {N53}
EF hand
SITE: 79-114
MOTIF: Ca+2-binding site
SITE: 92-103
EF hand
SITE: 115-150
MOTIF: Ca+2-binding site
SITE: 128-139
EF hand
SITE: 166-201
MOTIF: Ca+2-binding site
SITE: 179-190
EF hand
SITE: 203-238
MOTIF: Ca+2-binding site
SITE: 216-227
EF hand
SITE: 244-279
MOTIF: Ca+2-binding site
SITE: 257-268
EF hand
SITE: 280-315
MOTIF: Ca+2-binding site
SITE: 293-304
peptide motif {328-331}
Database Correlations
OMIM 602735
UniProt Q15293
Entrez Gene 5954
Kegg hsa:5954
References
UniProt :accession Q15293