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restin; CAP-Gly domain-containing linker protein 1; cytoplasmic linker protein 170 alpha-2; CLIP-170; Reed-sternberg intermediate filament-associated protein; cytoplasmic linker protein 1 (CLIP1, CYLN1, RSN)
Function:
- seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules
Structure: contains 2 CAP-Gly domains
Compartment:
- cytoplasm, cytoskeleton
- associated with the cytoskeleton
Alternative splicing: named isoforms=2; long, short
Expression:
- highly expressed in the Reed-sternberg cells of Hodgkin's disease
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 1427 aa
MW = 161 kD
COMPARTMENT: cytoplasm
MOTIF: Thr phosphorylation site {T45}
Ser phosphorylation site {S48}
CAP/Gly domain {78-120}
MOTIF: glycine residue (SEVERAL)
Thr phosphorylation site {T140}
serine-rich region {143-204}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S143}
Ser phosphorylation site {S147}
Thr phosphorylation site {T182}
Ser phosphorylation site {S195}
Ser phosphorylation site {S197}
Ser phosphorylation site {S200}
Ser phosphorylation site {S204}
CAP/Gly domain {232-274}
MOTIF: glycine residue (SEVERAL)
serine-rich region {304-331}
MOTIF: serine residue (SEVERAL)
coiled coil {350-1342}
MOTIF: Thr phosphorylation site {T822}
Ser phosphorylation site {S926}
peptide motif {1408-1421}
Database Correlations
OMIM 179838
UniProt P30622
Pfam PF01302
Entrez Gene 6249
Kegg hsa:6249
References
- UniProt :accession P30622
- Entrez Gene :accession 6249