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resistance & susceptibility to HIV1
Genetics:
1) coinfection with GB virus C affords some protection
2) trim5-alpha of rhesus monkey inhibits HIV-1 replication (reverse transcriptase). trim5-alpha of human does NOT
3) variations in CCR2 are associated with relative resistance to HIV1
- CCR2 gene p.Val64Ile
4) variations in CCR5
a) associated with susceptibility or resistance to HIV1
b) influence the rate of progression to AIDS after infection
c) loincs for CCR5 gene mutation, CCR5 gene c.794-825del
5) variations in CX3CR1
a) associated with rapid progression to AIDS
b) increased susceptibility to HIV infection & rapid progression to AIDS are associated with the Ile-249/ Met-280 haplotype
Related
HIV1 infection; human immunodeficiency virus-1 infection
Database Correlations
OMIM 609423
References
OMIM :accession 609423