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repressor of RNA polymerase 3 transcription MAF1 homolog (MAF1)
Function:
- element of the mTORC1 signaling pathway
- acts as a mediator of diverse signals
- inhibits RNA polymerase 3 transcription
- inhibits the de novo assembly of TFIIIB onto DNA
- phosphorylated at Ser-60, Ser-68 & Ser-75; the major sites of phosphorylation
- nuclear accumulation correlates with a concomitant dephosphorylation
- phosphorylation may attenuate its ability to inhibit RNA polymerase 3
- interacts with BRF2
Structure: belongs to the MAF1 family
Compartment: nucleus, cytoplasm
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 256 aa
MW = 29 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S60}
Thr phosphorylation site {T64}
Ser phosphorylation site {S65}
Ser phosphorylation site {S68}
Ser phosphorylation site {S70}
Ser phosphorylation site {S75}
Thr phosphorylation site {T212}
Ser phosphorylation site {S214}
Database Correlations
OMIM 610210
UniProt Q9H063
Pfam PF09174
Entrez Gene 84232
Kegg hsa:84232
References
UniProt :accession Q9H063