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replication initiator 1 (zinc finger protein 464, DHFR oribeta-binding protein RIP60, 60 kD replication initiation region protein, 60 kD origin-specific DNA-binding protein, ATT-binding protein, REPIN1, RIP60, ZNF464)

Function: - sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication - binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) & a 2nd, homologous ATT sequence of opposite orientation situated within the OBR zone - facilitates DNA bending near origins of replication - found in a complex with RIP60 & RIP100 Structure: - homodimers & homomultimers - contains 15 C2H2-type zinc fingers Compartment: nucleus Alternative splicing: named isoforms=2

General

DNA-binding protein zinc finger protein

Properties

SIZE: MW = 64 kD entity length = 567 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 57-79 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 85-107 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 116-138 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 145-168 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 177-199 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 236-258 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 264-286 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 292-314 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 325-372 MOTIF: proline residue (SEVERAL) Zn finger C2H2-type SITE: 375-397 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 403-425 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 431-453 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 459-481 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 487-509 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 515-537 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 543-565 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q9BWE0 Pfam PF00096

References

  1. UniProt :accession Q9BWE0
  2. Caddle et al Mol Cell Biol 10:6236 1990