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renal dipeptidase; microsomal dipeptidase; dipeptidase 1 (DPEP1, MDP, RDP)
Function:
- hydrolyzes a wide range of dipeptides
- implicated in renal metabolism of glutathione & its conjugates
- converts leukotriene D4 to leukotriene E4
- may play role in regulation of leukotriene activity
- inhibited by L-penicillamine (putative)
- hydrolysis of dipeptides
Cofactor: Zn+2
Structure:
- homodimer, disulfide-linked
- belongs to the peptidase M19 family
Compartment:
- apical cell membrane, lipid-anchor, GPI-anchor
- cell projection, microvillus membrane
- brush border membrane
General
dipeptidase
glycoprotein
glypiated protein
metalloprotein
oligomerizing protein
Properties
SIZE: entity length = 411 aa
MW = 46 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-16}
Zn+2-binding site
SITE: 36-36
Zn+2-binding site
SITE: 38-38
N-glycosylation site {N57}
cysteine residue {C87}
MODIFICATION: cysteine residue {C170}
Zn+2-binding site
SITE: 141-141
binding site
SITE: 168-168
FOR-BINDING-OF: Substrate
cysteine residue {C170}
MODIFICATION: cysteine residue {C87}
Zn+2-binding site
SITE: 214-214
Zn+2-binding site
SITE: 235-235
cysteine residue {C242}
MODIFICATION: cysteine residue {C274}
binding site
SITE: 246-246
FOR-BINDING-OF: Substrate
cysteine residue {C274}
MODIFICATION: cysteine residue {C242}
N-glycosylation site {N279}
binding site
SITE: 304-304
FOR-BINDING-OF: Substrate
N-glycosylation site {N332}
N-glycosylation site {N358}
cysteine residue {C377}
MODIFICATION: cysteine residue {C-INTERCHAIN}
glycosyl phosphatidylinositol [GPI] membrane anchor {N385}
Database Correlations
OMIM 179780
UniProt P16444
Pfam PF01244
Kegg hsa:1800
ENZYME 3.4.13.19
References
UniProt :accession P16444