Search
relaxin-3 receptor 2; relaxin family peptide receptor 4; G-protein coupled receptor 100; GPCR142 (RXFP4, GPR100, RLN3R2)
Function:
- receptor for relaxin-3, bradykinin & kallidin
- activity may be via Gi proteins as binding of ligand inhibits cAMP accumulation
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid & colon
Related
relaxin-3; prorelaxin H3; insulin-like peptide INSL7; insulin-like peptide 7 [Contains: relaxin-3 B chain; relaxin-3 A chain] (RLN3, INSL7, RXN3, ZINS4, UNQ6188/PRO20213)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 41 kD
entity length = 374 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-43}
MOTIF: N-glycosylation site {N5}
N-glycosylation site {N17}
transmembrane domain {44-64}
cytoplasmic loop {65-78}
transmembrane domain {79-99}
exoplasmic loop {100-116}
MOTIF: cysteine residue {C114}
MODIFICATION: cysteine residue {C191}
transmembrane domain {117-137}
cytoplasmic loop {138-154}
transmembrane domain {155-175}
exoplasmic loop {176-209}
MOTIF: cysteine residue {C191}
MODIFICATION: cysteine residue {C114}
transmembrane domain {210-230}
cytoplasmic loop {231-249}
transmembrane domain {250-270}
exoplasmic loop {271-281}
transmembrane domain {282-302}
cytoplasmic domain {303-374}
Database Correlations
OMIM 609043
UniProt Q8TDU9
Pfam PF00001
Kegg hsa:3394
References
UniProt :accession Q8TDU9