relaxin-3 receptor 1 (RLN3 receptor 1, relaxin family peptide receptor 3, somatostatin- and angiotensin-like peptide receptor, G protein-coupled receptor SALPR, GPCR135, RXFP3, RLN3R1, SALPR)

Function: - receptor for relaxin-3 - binding of relaxin-3 inhibits cAMP accumulation Structure: - belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - expressed predominantly in brain regions - expressed in substantia nigra & pituitary > hippocampus, spinal cord, amygdala, caudate nucleus, corpus callosum > cerebellum - in peripheral tissues, expressed in adrenal gland > pancreas, salivary gland, placenta, mammary gland, testis

Related

relaxin receptor relaxin-3; prorelaxin H3; insulin-like peptide INSL7; insulin-like peptide 7 [Contains: relaxin-3 B chain; relaxin-3 A chain] (RLN3, INSL7, RXN3, ZINS4, UNQ6188/PRO20213)

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 51 kD entity length = 469 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-81} MOTIF: N-glycosylation site {N36} N-glycosylation site {N40} transmembrane domain {82-102} cytoplasmic loop {103-119} transmembrane domain {120-140} exoplasmic loop {141-156} MOTIF: cysteine residue {C155} MODIFICATION: cysteine residue {C247} transmembrane domain {157-177} cytoplasmic loop {178-215} transmembrane domain {216-236} exoplasmic loop {237-270} MOTIF: cysteine residue {C247} MODIFICATION: cysteine residue {C155} transmembrane domain {271-291} cytoplasmic loop {292-329} transmembrane domain {330-350} exoplasmic loop {351-356} transmembrane domain {357-377} cytoplasmic domain {378-469}

Database Correlations

UniProt Q9NSD7 Pfam PF00001

References

UniProt :accession Q9NSD7