regulator of G-protein signaling 12 (RGS12)

Function: - inhibits signal transduction by increasing GTPase activity of G-alpha subunits increasing the amount of inactive GDP-bound form - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - contains 1 Goloco domain - contains 1 PDZ domain (DHR domain) - contains 1 PID domain - contains 2 RBD (Ras-binding) domains - contains 1 RGS domain Compartment: nucleus Alternative splicing: named isoforms=4 Expression: isoform 3 is brain specific

General

nuclear protein phosphoprotein regulator of G-protein signaling

Properties

SIZE: entity length = 1447 aa MW = 156 kD COMPARTMENT: cell nucleus MOTIF: PDZ domain NAME: PDZ domain SITE: 22-98 phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 228-340 RGS {715-832} Ser phosphorylation site {S850} Ser phosphorylation site {S874} Ser phosphorylation site {S889} Ser phosphorylation site {S934} Ser phosphorylation site {S940} RBD 1 {962-1032} RBD 2 {1034-1104} GoLoco domain {1187-1209}

Database Correlations

OMIM 602512 UniProt O14924 PFAM correlations Entrez Gene 6002 Kegg hsa:6002

References

UniProt :accession O14924