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regulatory factor X (RFX)
Function:
- binds the X1 box of MHC-II promoters
- forms cooperative DNA binding complexes with X2BP & CBF/NF-Y
- associates with CIITA/MHC2TA to form an active transcriptional complex
Structure:
- RFX consists of at least 3 different subunits: RFXAP, RFX5 & RFX-B/RFXANK; with each subunit representing a separate complementation group
Pathology:
- defects in the RFX-CIITA transcriptional complex are associated with bare lymphocyte syndrome type-2
Related
DNA-binding protein RFX2; regulatory factor X 2 (RFX2)
General
multisubunit protein
transcription factor (TF)
Properties
COMPARTMENT: cell nucleus
SUBUNITS: DNA-binding protein RFXANK
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 89-118
ankyrin repeat
NAME: ankyrin repeat
SITE: 123-152
ankyrin repeat
NAME: ankyrin repeat
SITE: 156-185
ankyrin repeat
NAME: ankyrin repeat
SITE: 189-218
ankyrin repeat
NAME: ankyrin repeat
SITE: 222-251
DNA-binding protein RFX5
MOTIF: DNA-binding motif
SITE: 92-168
MOTIF: DNA-binding motif
SITE: 95-167
regulatory factor X-associated protein
MOTIF: alanine-rich region {38-41}
MOTIF: alanine residue (SEVERAL)
nuclear translocation signal {163-178}
MOTIF: lysine-rich region {171-178}
MOTIF: lysine residue (SEVERAL)
References
- UniProt :accession O00287
- UniProt :accession O14593
- UniProt :accession P48382
Components
DNA-binding protein RFX5; regulatory factor X 5 (RFX5)
DNA-binding protein RFXANK; regulatory factor X subunit B; RFX-B; regulatory factor X-associated ankyrin-containing protein; ankyrin repeat family A protein 1 (RFXANK, ANKRA1, RFXB)
regulatory factor X-associated protein; RFX-associated protein; RFX DNA-binding complex 36 kD subunit (RFXAP)