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regenerating islet-derived protein 4 (Reg IV, REG-like protein, gastrointestinal secretory protein, REG4, GISP, RELP)
Function:
- role in inflammatory & metaplastic responses of the gastrointestinal epithelium (putative)
Structure: contains 1 C-type lectin domain
Compartment: secreted
Alternative splicing: named isoforms=3
Expression:
- expressed in GI tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas, small intestine > normal colon, stomach
- expressed in mucus-secreting cells and enterocyte-like cells.
- in small intestine expressed at the basal perinuclear zone of goblet cells
Pathology:
- greater expression in most colorectal tumors than in normal colon
- preferentialy expressed in mucinous tumors and in some cases neuro-endocrine tumors
- up-regulated by mucosal injury from active Crohn's disease or ulcerative colitis
- up-regulated in colorectal tumors
- up-regulated in epithelial cells at regenerating margins of peptic ulcers in the stomach & duodenum
General
glycoprotein
secreted protein
Properties
SIZE: MW = 18 kD
entity length = 158 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
C-type lectin {37-155}
MOTIF: N-glycosylation site {N50}
cysteine residue {C58}
MODIFICATION: cysteine residue {C154}
cysteine residue {C129}
MODIFICATION: cysteine residue {C146}
cysteine residue {C146}
MODIFICATION: cysteine residue {C129}
cysteine residue {C154}
MODIFICATION: cysteine residue {C58}
Database Correlations
UniProt Q9BYZ8
Pfam PF00059
References
- UniProt :accession Q9BYZ8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/REGIVID485.html