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recurrent invasive pneumococcal disease
defined as 2 episodes of infection due to pneumococcus occurring at least 1 month apart, whether caused by the same or different serotypes or strains of Streptococcus pneumoniae
Epidemiology:
- occurs in at least 2% of patients in most series
- most important known risk factor for subsequent invasive pneumococcal disease
Genetics:
- associated with defects in IRAK4 (type 1)
- associated with defects in IKBKG (type 2)
General
recurrent bacterial infection
genetic disease of the immune system
immunodeficiency; immunodeficiency syndrome
Database Correlations
OMIM correlations
References
- OMIM :accession 610799
- OMIM :accession 300640