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recoverin; cancer-associated retinopathy protein; protein CAR; visinin; frequinin; S-modulin (RCVRN, RCV1)

Function: - seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin - may be involved in the inhibition of the phosphorylation of rhodopsin (Ca+2-dependent); Ca+2-bound recoverin prolongs the photoresponse - binds two Ca+2; one with high affinity, the other with low affinity Structure: - belongs to the recoverin family - contains 4 EF-hand domains Expression: retina & pineal gland Pathology: - identified as the antigen in cancer-associated retinopathy (anti-Car antibody) Laboratory: - recoverin IgG Ab in serum/plasma - cancer-associated retinopathy Ab in serum

Related

anti-Car (recoverin) antibody

General

Ca+2 binding protein myristoylated protein

Properties

SIZE: entity length = 200 aa MW = 23 kD COMPARTMENT: cytoplasm CELL: photoreceptor cell WITHIN: retina MOTIF: myristoylation site SITE: G2 EFFECTOR-BOUND: myristate EF hand SITE: 25-60 EF hand SITE: 61-96 MOTIF: Ca+2-binding site SITE: 74-85 EF hand SITE: 97-132 MOTIF: Ca+2-binding site SITE: 110-121 EF hand SITE: 147-182

Database Correlations

OMIM 179618 UniProt P35243 Pfam PF00036 Entrez Gene 5957 Kegg hsa:5957

References

  1. UniProt :accession P35243
  2. Heizmann CW, Braun K. Changes in Ca(2+)-binding proteins in human neurodegenerative disorders. Trends Neurosci. 1992 Jul;15(7):259-64. Review. PMID: 1381122
  3. Hurley JB, Dizhoor AM, Ray S, Stryer L. Recoverin's role: conclusion withdrawn. Science. 1993 May 7;260(5109):740. PMID: 8097896