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receptor-type tyrosine-protein phosphatase T; R-PTP-T; RPTP-rho (PTPRT, R-PTP-T, RPTP-rho, KIAA0283)
Function:
- may be involved in both signal transduction & cellular adhesion in the CNS
- receptor tyrosine phosphatase
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 2B subfamily
- contains 4 fibronectin F3 modules
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 MAM domain
- contains 2 tyrosine-protein phosphatase domains
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in colon, lung, heart & testis, fetal & adult brain
- not detected in muscle & peripheral blood leukocytes
General
cell surface receptor
glycoprotein
tyrosine phosphatase (protein tyrosine phosphatate, PTP)
Properties
SIZE: entity length = 1463 aa
MW = 164 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-25}
MAM domain {30-191}
MOTIF: cysteine residue {*1} (2)
MODIFICATION: cysteine residue {*2}
cysteine residue {*2} (2)
MODIFICATION: cysteine residue {*1}
N-glycosylation site {N78}
N-glycosylation site {N98}
N-glycosylation site {N137}
immunoglobulin superfamily domain {193-284}
MOTIF: N-glycosylation site {N208}
cysteine residue {C213}
MODIFICATION: cysteine residue {C267}
cysteine residue {C267}
MODIFICATION: cysteine residue {C213}
fibronectin type III domain or F3 module {288-379}
fibronectin type III domain or F3 module {386-480}
MOTIF: N-glycosylation site {N421}
fibronectin type III domain or F3 module {481-584}
MOTIF: N-glycosylation site {N510}
N-glycosylation site {N547}
fibronectin type III domain or F3 module {589-726}
MOTIF: N-glycosylation site {N601}
N-glycosylation site {N654}
N-glycosylation site {N684}
transmembrane domain {767-787}
Tyrosine-protein phosphatase 1 {911-1165}
MOTIF: cysteine residue {C1106}
Tyrosine-protein phosphatase 2 {1197-1459}
MOTIF: cysteine residue {C1400}
Database Correlations
UniProt O14522
PFAM correlations
Kegg hsa:1112
ENZYME 3.1.3.48
References
UniProt :accession O14522