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Rb-related protein p130; retinoblastoma-like protein 2; RBR-2; PRB2; 130 kD retinoblastoma-associated protein; p130 (RBL2 RB2)
Function:
- regulator of entry into cell division
- directly involved in heterochromatin formation by maintaining overall chromatin structure & that of constitutive heterochromatin by stabilizing histone methylation
- recruits & targets histone methyltransferases SUV420H1 & SUV420H2, leading to epigenetic transcriptional repression
- controls histone H4 Lys-20 trimethylation.
- probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters
- Potent inhibitor of E2F-mediated trans-activation; associates preferentially with E2F5
- binds to cyclins A & E
- may act as a tumor suppressor
- interacts with AATF
- interacts with SUV420H1 & SUV420H2 (putative)
- component of the DREAM complex
- interacts with RINT1 during G0 & early G1 phase of the cell cycle,
- phosphorylated on Ser-639 & on 5 sites within the domain B phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis
Structure:
- belongs to the retinoblastoma protein (RB) family
- pocket domain 417-1024 contains:
- A domain: 417-616
- B domain: 828-1024
Compartment: nucleus
Expression: G0-restricted expression
Pathology:
- binds to & may be involved in the transforming capacity of the adenovirus E1A protein
Related
retinoblastoma-associated protein (pRb, Rb, pp110, p105-Rb, p110Rb, RB1)
retinoblastoma-associated protein-like p107 homolog; retinoblastoma-like protein 1; PRB1; 107 kD retinoblastoma-associated protein; p107 (RBL1)
General
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 1139 aa
MW = 128 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 9-16
MOTIF: proline residue (SEVERAL)
alanine-rich region {17-20}
MOTIF: alanine residue (SEVERAL)
glutamate-rich region {23-26}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S413}
Pocket; binds E1A {417-1024}
MOTIF: Thr phosphorylation site {T417}
Ser phosphorylation site {S639}
Thr phosphorylation site {T642}
Ser phosphorylation site {S672}
Ser phosphorylation site {S948}
Ser phosphorylation site {S952}
Ser phosphorylation site {S966}
Ser phosphorylation site {S971}
Ser phosphorylation site {S972}
Ser phosphorylation site {S973}
Thr phosphorylation site {T974}
Ser phosphorylation site {S981}
Ser phosphorylation site {S982}
Thr phosphorylation site {T986}
glutamate-rich region {998-1001}
MOTIF: glutamate residue (SEVERAL)
Thr phosphorylation site {T1019}
STATE: active state
Database Correlations
OMIM 180203
UniProt Q08999
PFAM correlations
Entrez Gene 5934
Kegg hsa:5934
References
- UniProt :accession Q08999
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/RBL2ID443.html
Component-of
DREAM complex (LINC complex)