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retinoblastoma [Rb] gene (Rb1)

Deletions or point mutations in the Rb gene occur in several tumors: 1) retinoblastoma 2) osteosarcoma 3) soft tissue sarcoma 4) small cell lung carcinoma 5) bladder carcinoma 6) breast cancer

Related

retinoblastoma retinoblastoma-associated protein (pRb, Rb, pp110, p105-Rb, p110Rb, RB1)

General

tumor suppressor gene or anti-oncogene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: retinoblastoma-associated protein LOCUS: human chromosome-13 Q14.1-14.2 MOTIF: transcription factor binding site transcriptional start site exon intron transcriptional termination site

Database Correlations

OMIM 180200

References

  1. OMIM :accession 180200
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 506