retinoblastoma-binding protein 9; RBBP-9; retinoblastoma-binding protein 10; RBBP-10; B5T overexpressed gene protein; Bog protein (RBBP9 BOG RBBP10)

Function: - may play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with Rb1 & the subsequent displacement of E2F-1 Compartment: cytoplasm, nucleus Alternative splicing: named isoforms=2 Expression: widely expressed Pathology: - expressed at higher levels in tumor tissues than in normal tissues

General

phosphoprotein retinoblastoma-binding protein

Properties

SIZE: entity length = 186 aa MW = 21 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T49} Retinoblastoma protein binding {56-70} Ser phosphorylation site {S135}

Database Correlations

OMIM 602908 UniProt O75884 Pfam PF06821 Kegg hsa:1074

References

UniProt :accession O75884