retinoblastoma-binding protein 8; RBBP-8; CtBP-interacting protein; CtIP; retinoblastoma-interacting protein & myosin-like; RIM (RBBP8, CTIP)

Function: - may modulate function of BRCA1 in transcriptional regulation, DNA repair, &/or cell cycle checkpoint control - interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, & with Rb1 - phosphorylated upon DNA damage, probably by ATM or ATR - hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1 - ubiquitination mediated by SIAH1 leads to proteasomal degradation (probable) Compartment: nucleus, predominantly nuclear

General

phosphoprotein retinoblastoma-binding protein

Properties

SIZE: entity length = 897 aa MW = 102 kD COMPARTMENT: cell nucleus MOTIF: coiled coil {28-157} Ser phosphorylation site {S327} binding site SITE: 490-494 FOR-BINDING-OF: C-terminal-binding protein 1 Ser phosphorylation site {S664} Ser phosphorylation site {S679} Ser phosphorylation site {S745} glutamate-rich region {750-753} MOTIF: glutamate residue (SEVERAL)

Database Correlations

OMIM 604124 MORBIDMAP 604124 UniProt Q99708 Entrez Gene 5932 Kegg hsa:5932

References

UniProt :accession Q99708