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retinoblastoma binding protein 6; RB binding protein 6; p53-associated cellular protein of testis; proliferation potential-related protein; protein P2P-R; retinoblastoma-binding Q protein 1; protein RBQ-1 (RBBP6, P2PR, PACT, RBQ1, My038)
Function:
- interacts with p53/TP53 & RB1 (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- contains 1 CCHC-type Zn+2 finger
- contains 1 DWNN domain
- contains 1 RING-type Zn+2 finger
Compartment:
- nucleus, nucleolus
- colocalizes with mitotic chromosomes
Alternative splicing: named isoforms=4
Expression:
- highly expressed in the placenta & testis
- expressed at lower levels in the brain, heart, kidney, liver & lung
Pathology:
- overexpressed in esophageal cancer
General
phosphoprotein
retinoblastoma-binding protein
ring finger protein
Properties
SIZE: MW = 202 kD
entity length = 1792 aa
COMPARTMENT: cell nucleus
MOTIF: DWNN {4-76}
Zn finger C2HC-type
SITE: 159-176
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S244}
Ser phosphorylation site {S245}
Ser phosphorylation site {S246}
Ser phosphorylation site {S247}
RING-finger {259-300}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S360}
Ser phosphorylation site {S516}
Ser phosphorylation site {S730}
Ser phosphorylation site {S770}
Ser phosphorylation site {S772}
Ser phosphorylation site {S861}
Ser phosphorylation site {S873}
RB1 interaction {982-1139}
Ser phosphorylation site {S1179}
Thr phosphorylation site {T1271}
Ser phosphorylation site {S1277}
Ser phosphorylation site {S1328}
Thr phosphorylation site {T1336}
binding site
SITE: 1433-1544
FOR-BINDING-OF: cellular tumor antigen p53
MOTIF: Thr phosphorylation site {T1468}
Database Correlations
OMIM 600938
UniProt Q7Z6E9
PFAM correlations
Entrez Gene 5930
Kegg hsa:5930
References
UniProt :accession Q7Z6E9