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retinoblastoma binding protein 2; histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; RBBP-2 (JARID1A, RBBP2, RBP2, KDM5A)
Function:
- histone demethylase that specifically demethylates Lys-4 of histone H3, thereby playing a central role in histone code
- does not demethylate histone H3 Lys-9, H3 Lys-27, H3 Lys-36, H3 Lys-79 or H4 Lys-20
- demethylates trimethylated & dimethylated but not monomethylated H3 Lys-4
- may stimulate transcription mediated by nuclear receptors
- may be involved in transcriptional regulation of Hox proteins during cell differentiation
- may participate in transcriptional repression of cytokines such as CXCL12
- interacts with the viral protein-binding domain of RB1
- interacts with ESR1, MYC, MYCN & LMO2
Cofactor: Fe+2 (putative)
Structure:
- belongs to the JARID1 histone demethylase family
- contains 1 ARID domain
- contains 1 JmjC domain
- contains 1 JmjN domain
- contains 3 PHD-type Zn+2 fingers
Compartment: nucleus, nucleolus
General
histone demethylase
phosphoprotein
retinoblastoma-binding protein
transcription factor (TF)
zinc finger protein
Properties
SIZE: entity length = 1722 aa
MW = 196 kD
COMPARTMENT: cell nucleus
MOTIF: JmjN {19-60}
ARID {84-174}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 293-343
EFFECTOR-BOUND: Zn+2
JmjC {437-603}
Ser phosphorylation site {S1111}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1161-1218
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S1331}
Ser phosphorylation site {S1603}
Ser phosphorylation site {S1608}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1645-1693
EFFECTOR-BOUND: Zn+2
LMO2 interaction {1654-1722}
MOTIF: Ser phosphorylation site {S1698}
Database Correlations
OMIM 180202
UniProt P29375
PFAM correlations
Entrez Gene 5927
Kegg hsa:5927
References
- UniProt :accession P29375
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/JARID1AID41033ch12p13.html